Synthesis of chitosan-based thermo- and pH-responsive porous nanoparticles by temperature-dependent self-assembly method and their application in drug release
學年 98
學期 1
出版（發表）日期 2009-10-01
作品名稱 Synthesis of chitosan-based thermo- and pH-responsive porous nanoparticles by temperature-dependent self-assembly method and their application in drug release
作品名稱（其他語言）
著者 Chuang, Chung-Yang; Don, Trong-Ming; Chiu, Wen-Yen
單位 淡江大學化學工程與材料工程學系
出版者 Hoboken: John Wiley & Sons, Inc.
著錄名稱、卷期、頁數 Journal of Polymer Science, Part A: Polymer Chemistry 47(19), pp.5126-5136
摘要 In this research, thermo- and pH-responsive chitosan-based porous nanoparticles were prepared by the temperature-dependent self assembly method. The chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) copolymer solution was prepared through polymerization of N-isopropylacrylamide (NIPAAm) monomer in the presence of chitosan (CS) solution using cerium ammounium nitrate as the initiator. Then, CS-g-PNIPAAm solution was diluted by deionized water and heated to 40 °C for CS-g-PNIPAAm self-assembly. After that, CS-g-PNIPAAm assembled to form micelles in which shell layer was CS. Crosslinking agent was used to reinforce the micelle structure to form nanoparticle. The molar ratio of CS/NIPAAm in the feed mixture was changed to investigate its effect on structure, morphology, thermal- and pH-responsive properties of the nanoparticles. TEM images showed that a porous structure of nanoparticles was developed. The synthesized nanoparticles carried positive charges on the surface and exhibited stimuli-responsive properties, and their mean diameter thus could be manipulated by changing pH value and temperature of the environment. The nanoparticles showed a continuous release of the encapsulated doxycycline hyclate up to 10 days during an in-vitro release experiment. These porous particles with environmentally sensitive properties are expected to be utilized in hydrophilic drug delivery system.
關鍵字 chitosan; drug release; micellization; nanoparticles; N-isopropylacrylamide; self-assembly; thermo-pH response
語言 en
ISSN 1099-0518
期刊性質 國外
收錄於 SCI EI
產學合作
通訊作者 Chiu, Wen-Yen
審稿制度
國別 USA
公開徵稿
出版型式 電子版
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