|標題：Sarcosine (N-Methylglycine) Treatment for Acute Schizophrenia: A Randomized, Double-Blind Study|
|作品名稱||Sarcosine (N-Methylglycine) Treatment for Acute Schizophrenia: A Randomized, Double-Blind Study|
|著者||Lane, Hsien-Yuan; Liu, Yi-Ching; Huang, Chieh-Liang; Chang, Yue-Cune; Liau, Chun-Hui; Perng, Cheng-Hwang; Tsai, Guochuan E.|
|出版者||Philadelphia: Elsevier Inc.|
|著錄名稱、卷期、頁數||Biological Psychiatry 63(1), pp.9–12|
Small molecules that enhance the N-methyl-D-aspartate (NMDA) neurotransmission have been shown to be beneficial as adjuvant therapy for schizophrenia. Among these compounds, sarcosine (a glycine transporter-I inhibitor), when added to an existing regimen of antipsychotic drugs, has shown its efficacy for both chronically stable and acutely ill patients. However, the efficacy of these agents as a primary antipsychotic agent has not yet been demonstrated.
Twenty acutely symptomatic drug-free patients with schizophrenia were randomly assigned under double-blind conditions to receive a 6-week trial of 2 g or 1 g of sarcosine daily.
Overall, patients in the 2-g group were more likely to respond as defined by a 20% or more reduction of the Positive and Negative Syndrome Scale total score, particularly among antipsychotic-naïve patients. However, there was no significant between-group difference in the sarcosine dose × time interaction analysis. Both doses were well tolerated with minimal side effects.
Although patients receiving the 2-g daily dose were more likely to respond, it requires further clarification whether the effect is limited to the antipsychotic-naive population. Future placebo- or active-controlled, larger-sized studies are needed to fully assess sarcosine’s effects.
|關鍵字||Glutamate; GlyT-1; N-methyl-D-aspartate; sarcosine; schizophrenia|
|通訊作者||Tsai, Guochuan E.|