教師資料查詢 | 類別: 期刊論文 | 教師: 張玉坤 Yue-cune Chang (瀏覽個人網頁)

標題:A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and D-serine add-on treatment for schizophrenia
學年98
學期2
出版(發表)日期2010/05/01
作品名稱A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and D-serine add-on treatment for schizophrenia
作品名稱(其他語言)
著者Lane, Hsien-Yuan; Lin, Ching-Hua; Huang, Yu-Jhen; Liao, Chun-Hui; Chang, Yue-Cune; Tasi, Guochuan E.
單位淡江大學數學學系
出版者Cambridge: Cambridge University Press
著錄名稱、卷期、頁數International Journal of Neuropsychopharmacology 13(4), pp.451-460
摘要Recent evidence indicates that enhancing N-methyl-D-aspartate (NMDA) neurotransmission with the treatment of NMDA/glycine site agonists, such as D-serine, or a glycine transporter-1 (GlyT-1) antagonist, N-methylglycine (sarcosine), can improve symptoms of schizophrenia. To compare these two novel approaches, 60 patients with chronic schizophrenia were enrolled into a 6-wk double-blind, placebo-controlled trial of add-on treatments at the reported effective dosages (2 g/d). Clinical assessments were conducted every other week. Treatment group x treatment duration interaction analysis by multiple linear regression showed that sarcosine was superior to placebo at all four outcome measures of Positive and Negative Syndrome Scale (PANSS) total (p=0.005), Scale for the Assessment of Negative Symptoms (SANS) (p=0.021), Quality of Life (QOL) (p=0.025), and Global Assessment of Functioning (GAF) (p=0.042). However, d-serine did not differ significantly from placebo in any measure. Sarcosine treatment was better than d-serine in effect sizes for all outcome measures. Sarcosine also surpassed placebo in most of the measures of five PANSS factors and five SANS subscales. All treatments were well tolerated. These findings suggest that the GlyT-1 inhibitor is more efficacious than the NMDA/glycine site agonist in treatment for schizophrenia, including life quality and global function, at the dosages tested.
關鍵字D-serine; glycine; N-methylglycine; NMDA; sarcosine; schizophrenia
語言英文
ISSN1461-1457
期刊性質國外
收錄於SCI
產學合作
通訊作者Tasi, Guochuan E.
審稿制度
國別英國
公開徵稿
出版型式紙本
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