教師資料查詢 | 類別: 研究報告 | 教師: 鄭廖平 CHENG, LIAO-PING (瀏覽個人網頁)

標題:親水與疏水性多孔型中空纖維薄膜之製備物性分析與薄膜表面改質用於固定去氧核醣核酸
學年99
學期1
出版(發表)日期2010/08/01
作品名稱親水與疏水性多孔型中空纖維薄膜之製備物性分析與薄膜表面改質用於固定去氧核醣核酸
作品名稱(其他語言)Preparation and Characterization of Porous Hydrophilic and Hydrophobic Hollow Fibe Membranes and Their Surface-Modification for Immobilization of DNA
著者鄭廖平
單位淡江大學化學工程與材料工程學系
描述計畫編號:{6};
研究期間201008~201107 ;
研究經費1,085,000
委託單位行政院國家科學委員會
摘要本研究主要探討聚偏二氟乙烯(PVDF)及聚醯胺(Nylon)多孔型中空纖維薄膜之製備及其改質以便應用於生醫領域。首先利用中空纖維模組製備聚偏二氟乙烯(PVDF)及聚醯胺(Nylon)中空纖維薄膜,探討製備薄膜時影響薄膜孔隙結構之參數,並製作出一系列不同孔隙結構之薄膜,以SEM、DSC、XRD等來作膜材物性分析。其次,利用ATRP法將聚甲基丙烯酯環氧丙烷(PGMA)接枝在PVDF中空纖維薄膜上,再利用PGMA的環氧基與DNA上的胺基反應形成共價鍵,而固定於薄膜表面,對各反應參數(例如反應溫度、反應濃度、pH等)加以探討。此外,利用錫觸媒使己二異氰酸酯其一端氰酸酯基與Nylon中空纖維薄膜反應,而另一端氰酸酯基用於後續與DNA反應而將DNA固定於薄膜表面,期望藉此開發出具有實用性的生醫材料。;This research project focuses on the formation and surface modification of poly(vinylidene fluoride) (PVDF) and nylon hollow fiber membranes, and their applications in the biomedical area. First of all, a series of hollow fiber membranes with different porous structures will be prepared by both isothermal wet-spining and dry-jet wet-spinning methods. The preparation parameters that affect the porous structures of the membranes (e.g., concentrations of the casting dope and the precipitation bath, additives, etc) will be studied. SEM, DSC and XRD measurement will be employed to characterize the formed hollow fiber membranes. Then, PVDF membranes will be grafted, on their surfaces, with poly(glycidyl methacrylate) (PGMA) using atom transfer radical polymerization (ATRP) method. Subsequently, DNA will be immobilized on the membranes by reaction with epoxy groups of the grafted PGMA. Various reaction parameters (e.g., reaction temperature, reactant concentrations, pH, etc.) will be the subjects of investigation. On the other hand, Nylon membranes will be surfaced modified by reaction with hexamethylene diisocyanate, HMDI) with the aids of stannum (Sn, catalyst). The remaining -NCO group of HMDI will be used to immobilized DNA on the membrane. It is hoped that this research will produce biomaterials that is of clinical significance.
關鍵字聚偏二氟乙烯; 聚醯胺; 多孔型薄膜; 中空纖維; 原子轉換自由基聚合法; DNA; Poly(vinylidene fluoride); Nylon; Hollow fiber; Porous membraneDNA; Atom transfer radical polymerization
語言中文
相關連結
Google+ 推薦功能,讓全世界都能看到您的推薦!