教師資料查詢 | 類別: 期刊論文 | 教師: 林諭男 I-nan Lin (瀏覽個人網頁)

標題:The effect of ultra-nanocrystalline diamond films on the proliferation and differentiation of neural stem cells
學年97
學期2
出版(發表)日期2009/07/01
作品名稱The effect of ultra-nanocrystalline diamond films on the proliferation and differentiation of neural stem cells
作品名稱(其他語言)
著者Chen, Ying-Chieh; Lee, Don-Ching; Hsiao, Chao-Yang; Chung, Yu-Fen; Chen, Huang-Chin; Joseph P. Thomas; Pong, Way-Faung; Tai, Nyan-Hwa; Lin, I-Nan; Chiu, Ing-Ming
單位淡江大學物理學系
出版者Amsterdam: Elsevier BV
著錄名稱、卷期、頁數Biomaterials 30(20), pp.3428-3435
摘要The interaction of ultra-nanocrystalline diamond (UNCD) with neural stem cells (NSCs) has been studied along with its surface modification in order to improve its function as a biomaterial. Hydrogen- and oxygen-terminated UNCD films were compared with standard grade polystyrene in terms of their impact on the growth, expansion and differentiation of NSCs. When NSCs were cultured on these substrates in low serum and without any differentiating factors, hydrogen-terminated UNCD films spontaneously induced cell proliferation and neuronal differentiation. Oxygen-terminated UNCD films were also shown to further improve neural differentiation, with a preference to differentiate into oligodendrocytes. Hence, controlling the surface properties of UNCD could manipulate the differentiation of NSCs for different biomedical applications. These observations raise the potential for the use of UNCD as a biomaterial for central nervous system transplantation and tissue engineering.
關鍵字Neural stem cells;Neural differentiation;Ultra-nanocrystalline diamond;ECM
語言英文
ISSN0142-9612
期刊性質國外
收錄於SCI;EI
產學合作
通訊作者Tai, Nyan-Hwa; Chiu, Ing-Ming
審稿制度
國別荷蘭
公開徵稿
出版型式紙本
相關連結
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