Effect of cell membrane structure of human erythrocyte on its electrophoresis
學年 92
學期 1
出版（發表）日期 2003-11-01
作品名稱 Effect of cell membrane structure of human erythrocyte on its electrophoresis
作品名稱（其他語言）
著者 Hsu, Jyh-ping; Lin, Sung-hwa; 曾琇瑱; Tseng, Shio-jenn
單位 淡江大學數學學系
出版者 Elsevier
著錄名稱、卷期、頁數 Colloids and Surfaces B: Biointerfaces 32(3), pp.203-212
摘要 The electrophoretic behavior of human erythrocyte is investigated theoretically. The present analysis extends previous studies to that the effect of the membrane structure of a cell is taken into account. The result obtained provides a useful tool for the estimation of the surface properties of human erythrocyte through electrophoretic measurements. Fitting the present model to the experimental data of Haydon and Seaman [Arch. Biochem. Biophys. 122 (1967) 126], for example, reveals that the surface charge of erythrocyte arises mainly from the dissociation of three functional groups, which bond to different sites on cell membrane : (a) N-acetylneuraminic acid (sialic acid) with pKHANaa=2.6, (b) some kind of α-carboxylic acid with pKHAα−ca=3.35, (c) weak amino base functional group with pKBH+=8.5. The distribution of Na+ in the protein layer of a cell is found to vary with the pH of the bulk liquid phase, the possible implication of this phenomenon to cell physiology is discussed.
關鍵字 Cell membrane structure;Human erythrocyte;Electrophoresis;Mathematical model
語言 en
ISSN 0927-7765
期刊性質 國內
收錄於
產學合作
通訊作者
審稿制度 否
國別 TWN
公開徵稿
出版型式 ,電子版
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