教師資料查詢 | 類別: 期刊論文 | 教師: 陳主智 CHEN CHU-CHIH (瀏覽個人網頁)

標題:A statistical assessment on the stochastic relationship between biomarker concentrations and environmental exposures
學年93
學期1
出版(發表)日期2004/12/01
作品名稱A statistical assessment on the stochastic relationship between biomarker concentrations and environmental exposures
作品名稱(其他語言)
著者陳主智; Chen, Chu-chih; Wu, Kuen-yuh; Chang, Ming J. W.
單位淡江大學數學學系
出版者Springer
著錄名稱、卷期、頁數Stochastic Environmental Research and Risk Assessment 18(6), pp.377-385
摘要Biological monitoring has gradually developed into a powerful tool in the identification and quantification of exposures to occupational and/or environmental hazards in environmental and occupational health studies. Aggregate individual exposure to pollutants and evidence for exploring dose-response relationship in the human bodies can be assessed through biomarker measurements. The existence of inter-individual differences among a study population, however, often hampers the relationship assessment between exposure and the biomarker. In this paper, a statistical random effects model identified from a simplified one-compartment pharmacokinetic model is applied to establish the dynamic relationship between a biomarker and its corresponding external exposure. This model avoids the complex parameter estimation problem encountered using a physiologically based pharmacokinetic (PBPK) model, and incorporates inter-individual variations often ignored in the usual regression approach. In addition, the relevant parameters for the generic kinetic process can be estimated directly. As a guideline for preliminary sampling strategy, tables of required sample sizes and the number of repeated measurements to achieve the desired statistical power and test efficiency are given. The currently established biological exposure indices (BEIs) for benzene and methyl chloroform are employed to illustrate the impact of inter- individual variations on the percentages of protection for workers exposed to the threshold limit value (TLV) of the corresponding chemical.
關鍵字Biological exposure indices;Inter-individual difference;Random-effects model;Physiologically-based pharmacokinetic model;Sampling design Threshold limit value
語言英文
ISSN1436-3240
期刊性質國外
收錄於
產學合作
通訊作者
審稿制度
國別中華民國
公開徵稿
出版型式,電子版
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