教師資料查詢 | 類別: 期刊論文 | 教師: 陳曜鴻 CHEN, YAU-HUNG (瀏覽個人網頁)

標題:A novel zebrafish mutant with wavy-notochord: An effective biological index for monitoring the copper pollution of water from natural resources
學年99
學期2
出版(發表)日期2011/02/01
作品名稱A novel zebrafish mutant with wavy-notochord: An effective biological index for monitoring the copper pollution of water from natural resources
作品名稱(其他語言)
著者Chen, Yau-hung; Lin, Ji-sheng
單位淡江大學生命科學研究所
出版者Hoboken: John Wiley &; Sons, Inc.
著錄名稱、卷期、頁數Environmental Toxicology 26(1), pp.103-109
摘要We identified a novel zebrafish mutant that has wavy-notochord phenotypes, such as severely twisted notochord and posterior malformations, but has normal melanocytes. Histological evidences showed that proliferating vacuolar cells extended their growth to the muscle region, and consequently caused the wavy-notochord phenotypes. Interestingly, those malformations can be greatly reversed by exposure with copper, suggesting that copper plays an important role on wavy-notochord phenotypes. In addition, after long-term copper exposure, the surviving larvae derived from wavy-notochord mutants displayed bone malformations, such as twisted axial skeleton and osteophyte. These phenotypic changes and molecular evidences of wavy-notochord mutants are highly similar to those embryos whose lysyl oxidases activities have been inactivated. Taken together, we propose that (i) the putative mutated genes of this wavy-notochord mutant might be highly associated with the lysyl oxidase genes in zebrafish; and (ii) this fish model is an effective tool for monitoring copper pollution of water from natural resources.
關鍵字bone;copper;notochord;toxicity;zebrafish
語言英文
ISSN1520-4081
期刊性質國外
收錄於SCI;EI
產學合作
通訊作者Chen, Yau-hung
審稿制度
國別美國
公開徵稿
出版型式紙本
相關連結
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