教師資料查詢 | 類別: 期刊論文 | 教師: 張玉坤 Yue-cune Chang (瀏覽個人網頁)

標題:Renal protective effect of sacubitril/valsartan in patients with heart failure
學年
學期
出版(發表)日期2021/12/01
作品名稱Renal protective effect of sacubitril/valsartan in patients with heart failure
作品名稱(其他語言)
著者Hui Ling Hsieh; Chun You Chen; Cheng Hsien Chen; Shih Chang Hsu; Wen Cheng Huang; Yuh Mou Sue; Feng Yen Lin; Chun Ming Shih; Yue Cune Chang; Po Hsun Huang; Chung Te Liu
單位
出版者
著錄名稱、卷期、頁數Scientific Reports 11 (1), 4593
摘要Sacubitril/valsartan is a combined neprilysin inhibitor/angiotensin II receptor blocker designed for
treatment of heart failure (HF). Nonetheless, its renal protective efect remained an issue of debate.
This retrospective cohort study investigated the renal protective efect of sacubitril/valsartan in HF
patients. HF patients on sacubitril/valsartan or valsartan for > 30 days were matched for gender, age,
estimated glomerular fltration rate (eGFR), and left ventricular ejection fraction (LVEF) to be enrolled
into analysis. The follow-up period was 18 months. The outcomes included end eGFR, renal function
decline defned as 20% reduction of eGFR, mortality, and HF-related hospitalization. Each group had
137 patients after matching. The mean age was 72.7 years and 65.7% were male. Mean eGFR was
70.9 mL/min/1.73 m2
and LVEF was 54.0% at baseline. Overall, the eGFR of sacubitril/valsartan groups
was signifcantly higher than valsartan group at the end (P< 0.01). Subgroup analysis showed that
the diference in eGFR was signifcant in subgroups with LVEF≥ 40% or eGFR≥ 60 mL/min/1.73 m2
.
Multivariate Cox regression model showed that sacubitril/valsartan group had signifcantly reduced
risk for renal function decline (hazard ratio: 0.5, 95% confdence interval: 0.3–0.9). Kaplan–Meier
curve showed no diference in the risk for cardiovascular mortality, all-cause mortality or HF-related
hospitalization. We showed renal protective efect of neprilysin inhibition in HF patients and specifed
that subgroups with LVEF ≥ 40% or eGFR≥ 60 mL/min/1.73 m2
were sensitive to this efect, suggesting
an optimal subgroup of this treatment
關鍵字
語言英文(美國)
ISSN20452322
期刊性質國外
收錄於SCI;
產學合作
通訊作者
審稿制度
國別美國
公開徵稿
出版型式,電子版
相關連結
SDGs
  • 良好健康和福祉
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