期刊論文
| 學年 | 113 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2025-07-04 |
| 作品名稱 | Divergent Synthesis of Heterotricyclic Compounds from γ-Alkynyl-1,3-diketones via Base-Mediated Tandem Annulations |
| 作品名稱（其他語言） | |
| 著者 | Ming-Yang Chang; Yu-Guang Lin; Fang-Yi Jen; Yi-En Liang; Hsi Ho; Wen-Tai Li |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Organic Letters 27(26), p.7182-7187 |
| 摘要 | This paper presents a novel base-mediated strategy for the divergent synthesis of oxygen- and nitrogen-containing heterotricyclic compounds, furo[3,2-c]chromene and furo[3,2-c]quinolone, from γ-alkynyl 1,3-diketones without the use of transition metals. These one-pot tandem reaction methodologies demonstrate remarkable versatility, enabling base-mediated O-attack via 5-exo-dig or C-attack intramolecular cyclization onto the alkyne, leading to the formation of furo[3,2-c]chromene or xanthone products. Additionally, sequential reactions involving regioselective condensation followed by tandem annulation afford furo[3,2-c]quinolone. These approaches leverage precisely controlled reaction conditions to direct selective annulation pathways, facilitating the construction of diverse heterocyclic frameworks with significant pharmaceutical potential. |
| 關鍵字 | |
| 語言 | en |
| ISSN | 1523-7052; 1523-7060 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 否 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | ,電子版,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/129592 ) |