期刊論文
| 學年 | 113 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2025-05-12 |
| 作品名稱 | A Self-Expanding Nitinol Fixation System for Atrial Leadless Pacemakers: Biomechanical Design and Evaluation. |
| 作品名稱（其他語言） | |
| 著者 | Yu-Tzu Wang; Yu-Sheng Lin; Yu-Wei Lin; Chun-Ming Chang; Lung-Sheng Wu; Chao-Sung Lai; Pao-Hsien Chu. |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Bioengineering 12(5), 512 |
| 摘要 | Atrial leadless pacemakers (ALPMs) offer a minimally invasive solution for patients requiring atrial pacing, but current designs face significant challenges related to fixation stability, perforation risk, and retrievability. This study presents a novel self-expanding nitinol fixation system designed for deployment within the left atrial appendage (LAA), incorporating a flexible adapter for secure pacemaker engagement and retrieval. Finite-element simulations were conducted to assess gravitational displacement across different anatomical orientations, and fixture-expansion behavior was analyzed under various mesh configurations. The pacemaker drop analysis results demonstrated minimal displacement in neutral and upward-tilted LAA models, with increased instability observed in downward-tilted orientations. The fixture-expansion study showed that the 0.2 mm mesh design provided adequate mechanical strength and strain tolerance while maintaining a compact profile. This novel fixation system improves current ALPM limitations by providing stable, retrievable anchoring and favorable biomechanical performance. It may also serve as a dual-function platform for atrial pacing and stroke prevention when integrated with a left atrial appendage (LAA) occluder. These findings support further preclinical validation for clinical translation. |
| 關鍵字 | leadless pacemaker; left atrial appendage (LAA); nitinol alloy; finite-element analysis; fixture |
| 語言 | en |
| ISSN | 2306-5354 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 否 |
| 國別 | CHE |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/129169 ) |