期刊論文
| 學年 | 114 |
|---|---|
| 學期 | 1 |
| 出版（發表）日期 | 2026-01-01 |
| 作品名稱 | Alditols in complex with boronophenylalanine for improving aqueous solubility for boron neutron capture therapy |
| 作品名稱（其他語言） | |
| 著者 | Teng-San Hsieh; Yu-Hou Yu; Zhen-Fan You; Rong-Jiun Sheu; Jin-Pei Deng; Chung-Shan Yu |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | RSC Pharmaceutics (1) |
| 摘要 | Boron neutron capture therapy (BNCT) aimed at treating brain tumors is deteriorated by the poor aqueous solubility of the BNCT agent, boronophenylalanine (BPA). Solubilizers, such as sorbitol, mannitol and xylitol and their mixing formulas, the storage temperature and time, acid adjusters, and antioxidants, as well as lyophilization conditions were studied. HPLC, 1H-NMR, and scanning electron microscopy (SEM) were used to investigate the alditol–BPA samples. HPLC results showed that the stability of sorbitol–BPA samples improved when the antioxidant Na2S2O5 was used, 98.25 ± 0.31% vs. 94.37 ± 1.24%, P < 0.05. The osmolality ratio of sorbitol–BPA, 0.83 ± 0.03, was lower than that of saline, 1.0, making it physiologically compatible. SEM results of the lyophilized samples showed a proportion of sorbitol–BPA vs. H2O in a molar ratio of 1[thin space (1/6-em)]:[thin space (1/6-em)]10. Sorbitol was the best solubilizer according to the 1H-NMR-derived integral ratio in the decreasing order of sorbitol–BPA, mannitol–BPA, fructose–BPA and xylitol–BPA with the values of 12.15 ± 1.30, 6.65 ± 0.61, 6.13 ± 1.90 and 4.77 ± 0.72, P < 0.05, respectively. The antioxidant Na2S2O5 improved the stability of sorbitol–BPA at 25 °C according to the 1H-integral ratio of 17.60 ± 2.15 vs. 12.67 ± 1.62, P = 0.10. The differences were not statistically significant. From both the HPLC and 1H-integral results, sorbitol emerges as the optimal solubilizer for PBA for further in vivo studies. |
| 關鍵字 | |
| 語言 | zh_TW |
| ISSN | 2976-8713 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | Chung-Shan Yu |
| 審稿制度 | 是 |
| 國別 | DEU |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/128640 ) |