期刊論文
| 學年 | 114 |
|---|---|
| 學期 | 1 |
| 出版（發表）日期 | 2025-12-23 |
| 作品名稱 | Photodynamic Agents of Synthetic Curcuminoids with Antibacterial and Anticancer Activities |
| 作品名稱（其他語言） | |
| 著者 | Sung-Jen Hung; Lo-Yun Chiang; Yi-An Hong; Kai-Chih Chang; Yang-Je Cheng; Hsin-Ying Wu; Hussana Hamid; Anren Hu; Tzenge-Lien Shih; Hao-Ping Chen |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Organics 7(1), p.1 |
| 摘要 | Our previous study demonstrated that thiophene-substituted synthetic curcumin analogs possessed better antibacterial activity and stability than natural curcumin, demethoxycurcumin, or bisdemethoxycurcumin in antibacterial photodynamic therapy (aPDT). In addition, the activity of the furan-substituted analogs was weaker than that of the thiophene-substituted compounds. As oxygen, sulfur, and selenium belong to the same group in the periodic table, the antibacterial and anticancer activities of these three different elemental analogs were compared and investigated. The thiophene-substituted analog (compound 3) exhibited the most potent antibacterial activity in aPDT experiments. However, the furan-substituted analog (compound 1) exhibited the most potent anticancer activity. These results indicate that the differences in atomic radii or energy levels in these compounds produce different cell-attack results on generated free radicals. Ruthenium(II) complexes have a good reputation for use in PDT for cancer treatment. Our results show that complexation of ruthenium(II) with thiophene-substituted curcumin analogs does not enhance their antibacterial or anticancer activity. |
| 關鍵字 | curcuminoid; photodynamic inactivation; ruthenium(II) complexes; Staphylococcus aureus; Staphylococcus epidermis |
| 語言 | en |
| ISSN | 2673-401X |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | Tzenge-Lien Shih |
| 審稿制度 | 是 |
| 國別 | CHE |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/128336 ) |