期刊論文
| 學年 | 113 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2025-04-23 |
| 作品名稱 | New record of potential tyrosinase inhibitory, antioxidant and photoprotective effects of Vietnamese Castanea mollissima extracts |
| 作品名稱（其他語言） | |
| 著者 | Thi Thu Le Vu; San-Lang Wang; Quang Tan Luc; Tien Lam Do; Thi Bich Hanh Dam; Thi Kim Phung Phan; Thanh Thao Nguyen; Phuc Hoang Tran; Anh Dzung Nguyen; Van Bon Nguyen |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Chemistry & Biodiversity, e202500994 |
| 摘要 | In this study, the potential anti-tyrosinase, antioxidant, and ultraviolet (UV) absorption efficiency of the extracts of different parts of Castanea mollissima were evaluated. The leaf extract exhibited the most potential antioxidant effect with 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging abilities of >90%. C. mollissima extracts showed high UV-A and UV-B absorption efficiency. In addition, screening of the leaf extract demonstrated C. mollissima leaves as a rich source of tyrosinase inhibitors with maximum inhibitory activity and half-maximal inhibitory concentration values of 96% and 336.43 µg/mL, respectively. This is the first-ever report of screening of leaf extract for its potential activities. Eighteen phyto-compounds were identified from the C. mollissima leaf extract using gas chromatography-mass spectrometry and high-performance liquid chromatography techniques. Of these, the content of compounds 10, 11, 12, 13, 14, and 16 in the C. mollissima leaf extract was significantly high (14.35-88.42 µg/g). The molecular docking, absorption, distribution, metabolism, excretion, and toxicity, and Lipinski's rule of five analyses indicated high interaction efficacy of all the major compounds (docking score values of -6.75 to -8.89 kcal/mol) with the target enzyme tyrosinase, had drug properties, and were non-toxic for human use. |
| 關鍵字 | Castanea mollissima; antioxidants; cosmetics; photoprotective agents; tyrosinase inhibitor |
| 語言 | en |
| ISSN | 1612-1880; 1612-1872 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 是 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/127655 ) |