期刊論文
| 學年 | 110 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2022-04-04 |
| 作品名稱 | Protection-Free Strategy for the Synthesis of Boro-Depsipeptides in Aqueous Media under Microwave-Assisted Conditions |
| 作品名稱（其他語言） | |
| 著者 | Shuo-Bei Qiu, Pei-Yao Liu, Bo-Cheng Wang, Pin-Rui Chen, Jing-Han Xiao, Ting-Yu Hsu, Kuan-Lin Pan, Zhi-Yin Lai, Yi-Wei Chen, Ying-Chuan Chen, Jen-Kun Chen, and Po-Shen Pan |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Molecules 2022 27(7), 2325 |
| 摘要 | In this report, 19 boron-containing depsipeptides were synthesized via microwave-assisted Passerini three-component reaction (P-3CR) in an aqueous environment. The linker-free DAHMI fluorescent tagging approach was used on selected boron-containing compounds to study the relationship between their structures and their level of cellular uptake of HEK293 cells. The biological data retrieved from the DAHMI experiments indicated that while the structures of tested compounds may be highly similar, their bio-distribution profile could be vastly distinctive. The reported optimized one-pot synthetic strategy along the linker-free in vitro testing protocol could provide an efficient platform to accelerate the development of boron-containing drugs. |
| 關鍵字 | depsipeptide(s);α-acyloxyamide;passerini;multicomponent;microwave-assisted;DAHMI;boronic acid |
| 語言 | en_US |
| ISSN | 1420-3049 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | Po-Shen Pan |
| 審稿制度 | 是 |
| 國別 | CHE |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/124324 ) |