期刊論文
| 學年 | 110 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2022-06-01 |
| 作品名稱 | Molybdenum trioxide hybridized kaempferol: double-powered nanosystem for salvaging oxidative stress and electrochemical immunoprobing of interleukin-6 |
| 作品名稱（其他語言） | |
| 著者 | G. R. Pandey; P. Kanagavalli; K. Karnam; K. T. Arul; P. Monisha; C. L. Dong; J. L. Chen; M. Veerapandian; J. Nirmal |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Materials Today Chemistry 24, 100809 |
| 摘要 | Intracellular reactive oxygen species (iROS) are the culprit in inflammation-linked diseases. Excessive radical generation triggers an inflammation cascade involving interleukin-6 (IL-6) and other cytokines release, causing oxidative stress to cells. Developing healthcare materials with dual-functionality controlling iROS and diagnosing IL-6 would be extremely beneficial for chronic inflammatory disease management. Herein, molybdenum trioxide hybridized kaempferol nanoparticles (MoHK NPs) have been synthesized with iROS scavenging and in situ electrochemical redox property for immunoassay of IL-6. Physicochemical integrity of nanosystem comprising MoHK NPs is characterized by X-ray absorption/photoelectron, Raman, and fourier transform infrared (FT-IR) spectroscopy as well as scanning transmission electron microscopy–high-angle annular dark field microscopic analysis. In vitro radical scavenging mechanism of MoHK NPs was studied by electron paramagnetic spectroscopy. Distinctly, these MoHK NPs exhibit a clinically significant antioxidant function and cytocompatibility with RAW 264.7 macrophage cell line. Bioaffinity layer–assisted monoclonal antibodies of IL-6 immobilized on MoHK electrode enable superior selectivity, electrochemical signal transduction (sensitivity 0.63 μA/fM/cm2), and rapid analytical response time even at ultralow IL-6 concentrations (detection limit 0.91 fM). This work demonstrates that hybridizing redox-active and antioxidant-rich phytochemical on metal oxide nanosystem can be a promising strategy for multifunctional theranostics. |
| 關鍵字 | |
| 語言 | en_US |
| ISSN | 2468-5194 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 是 |
| 國別 | GBR |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/124078 ) |