期刊論文
| 學年 | 109 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2021-04-15 |
| 作品名稱 | Salvage Boron Neutron Capture Therapy for Malignant Brain Tumor Patients in Compliance with Emergency and Compassionate Use: Evaluation of 34 Cases in Taiwan |
| 作品名稱（其他語言） | |
| 著者 | Yi-Wei Chen; Yi-Yen Lee; Chun-Fu Lin; Po-Shen Pan; Jen-Kun Chen; Chun-Wei Wang; Shih-Ming Hsu; Yu-Cheng Kuo; Tien-Li Lan; Sanford P. C. Hsu; Muh-Lii Liang; Robert Hsin-Hung Chen; Feng-Chi Chang; Chih-Chun Wu; Shih-Chieh Lin; Hsiang-Kuang Liang; Jia-Cheng Lee; Shih-Kuan Chen; Hong-Ming Liu; Jinn-Jer Peir; Ko-Han Lin; Wen-Sheng Huang; Kuan-Hsuan Chen; Yu-Mei Kang; Shueh-Chun Liou; Chun-Chieh Wang; Ping-Ching Pai; Chih-Wei Li; Daniel Quah Song Chiek; Tai-Tong Wong; Shih-Hwa Chiou; Yee Chao; Hiroki Tanaka; Fong-In Chou; Koji Ono |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Biology 10(4), 334 |
| 摘要 | Although boron neutron capture therapy (BNCT) is a promising treatment option for malignant brain tumors, the optimal BNCT parameters for patients with immediately life-threatening, end-stage brain tumors remain unclear. We performed BNCT on 34 patients with life-threatening, end-stage brain tumors and analyzed the relationship between survival outcomes and BNCT parameters. Before BNCT, MRI and 18F-BPA-PET analyses were conducted to identify the tumor location/distribution and the tumor-to-normal tissue uptake ratio (T/N ratio) of 18F-BPA. No severe adverse events were observed (grade ≥ 3). The objective response rate and disease control rate were 50.0% and 85.3%, respectively. The mean overall survival (OS), cancer-specific survival (CSS), and relapse-free survival (RFS) times were 7.25, 7.80, and 4.18 months, respectively. Remarkably, the mean OS, CSS, and RFS of patients who achieved a complete response were 17.66, 22.5, and 7.50 months, respectively. Kaplan–Meier analysis identified the optimal BNCT parameters and tumor characteristics of these patients, including a T/N ratio ≥ 4, tumor volume < 20 mL, mean tumor dose ≥ 25 Gy-E, MIB-1 ≤ 40, and a lower recursive partitioning analysis (RPA) class. In conclusion, for malignant brain tumor patients who have exhausted all available treatment options and who are in an immediately life-threatening condition, BNCT may be considered as a therapeutic approach to prolong survival. |
| 關鍵字 | BNCT;glioblastoma;T/N ratio;T/B ratio;radioresistance |
| 語言 | en_US |
| ISSN | 2079-7737 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | Fong-In Chou |
| 審稿制度 | 0 |
| 國別 | CHE |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/120757 ) |