期刊論文
| 學年 | 106 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2018-02-01 |
| 作品名稱 | Isolation and identification of novel α-amylase inhibitors from Euonymus laxiflorus Champ |
| 作品名稱（其他語言） | |
| 著者 | Nguyen VB; Wang SL; Nguyen AD; Vo TPK; Zhang LJ; Nguyen QV; Kuo YH |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Research on Chemical Intermediates 44(2), p.1411-1424 |
| 摘要 | Euonymus laxiflorus Champ. (ELC) has been reported to possess potential antidiabetic activity. The aim of this study is to isolate and identify the active compounds in ELC extract. Application of effective techniques including Diaoin, octadecylsilane opened columns, dialysis, and preparative high-performance liquid chromatography (HPLC) coupled with a biologically guided assay resulted in isolation of 11 novel active compounds. Five compounds were identified as new α-amylase inhibitors (αAIs), viz. walterolactone A/B β-D-pyranoglucoside (1), schweinfurthinol 9-O-β-D-pyranoglucoside (10), 1-O-(3-methyl)-butenoyl-myoinositol (11), leonuriside (13), and (3,5-dimethoxy-4-hydroxyphenol) -1-O-β-D-(6′-O-galloyl)-glucopyranoside (21). Among these inhibitors, three compounds (1, 10, 11) were characterized as new. Another six known compounds (2, 9, 16, 17, 18, 19) were determined as phenolic. Notably, six compounds (1, 2, 9, 13, 16, 17) demonstrated significant activity, comparable to or higher than that of acarbose, a commercial antidiabetic drug, based on t test ranking. The relationship between the chemical structures and bioactivity of the inhibitors is also reported. |
| 關鍵字 | α-amylase inhibitor;Euonymus laxiflorus Champ.;Medicinal plants;Diabetes;Obesity;Bioactive compounds |
| 語言 | en |
| ISSN | 0922-6168 |
| 期刊性質 | 國內 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | WANG San-Lang |
| 審稿制度 | 是 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/112608 ) |