期刊論文
| 學年 | 104 |
|---|---|
| 學期 | 1 |
| 出版（發表）日期 | 2015-10-01 |
| 作品名稱 | THE EFFECTS OF EXTENSIONAL STRESS ON RED BLOOD CELL HEMOLYSIS |
| 作品名稱（其他語言） | |
| 著者 | Jen-Hong Yen; Sheng-Fu Chen; Ming-Kai Chern; Po-Chien Lu |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Biomedical Engineering: Applications, Basis and Communications 27(5), pp.1550042(11 pages) |
| 摘要 | Arti¯cial prostheses create non-physiologic °ow conditions with stress forces that may induce blood cell damage, particularly hemolysis. Earlier computational °uid dynamics (CFD) prediction models based on a quanti¯ed power model showed signi¯cant discrepancies with actual hemolysis experiments. These models used the premise that shear stresses act as the primary force behind hemolysis. However, additional studies have suggested that extensional stresses play a more substantial role than previously thought and should be taken into account in hemolysis models. We compared extensional and shear stress °ow ¯elds within the contraction of a short capillary with sharp versus tapered entrances. The °ow ¯eld was calculated with CFD to determine stress values, and hemolysis experiments with porcine red blood cells were performed to correlate the e®ects of extensional and shear stress on hemolysis. Our results support extensional stress as the primary mechanical force involved in hemolysis, with a threshold value of 1000 Pa under exposure time less than 0.060 ms. |
| 關鍵字 | Hemolysis;Computational;Fluid dynamics;Extensional stress;Short capillary |
| 語言 | en |
| ISSN | 1016-2372 ; 1793-7132 |
| 期刊性質 | 國外 |
| 收錄於 | SCI EI |
| 產學合作 | |
| 通訊作者 | Po-Chien Lu |
| 審稿制度 | 否 |
| 國別 | SGP |
| 公開徵稿 | |
| 出版型式 | ,電子版,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/104675 ) |