期刊論文

標題 Condensed multilamellar structure of a complex of DNA with an amphiphilic block copolymer
學年 96
學期 2
出版(發表)日期 2008/06/01
作品名稱 Condensed multilamellar structure of a complex of DNA with an amphiphilic block copolymer
作品名稱(其他語言)
著者 Su, Chun-jen; Yeh, Sheng-wei; Lai, Wei-chi; Chen, Hsin-lung; M. Habibur Rahman; Wu, Ren-jye; Lin, Hsien-kuang; Liu, Wen-liang
單位 淡江大學化學工程與材料工程學系
出版者 RSC Publishing
著錄名稱、卷期、頁數 Soft Matter 4(6), pp.1306-1312
摘要 Deoxyribonucleic acid (DNA) is an attractive building block for self-assembled nanostructures, because the anionic phosphate group and the base moiety allow it to bind with a broad spectrum of organic and inorganic species through ionic and hydrogen bonding. Here we present a hierarchical structure formed by the ionic complex of DNA with an amphiphilic block copolymer comprising a cationic block. Upon the complexation the cationic block chains wrap around DNA for charge matching and the microphase separation between the hydrophobic block and the hydrophilic component yields a multilamellar structure with liquid crystalline ordering of the DNA chains condensed in the hydrophilic microdomains. Each hydrophilic lamellar domain is found to contain two DNA sublayers separated by a thin water gap, with each sublayer comprising two rows of densely packed DNA chains to lower the interfacial free energy for the present system with strong polar–nonpolar repulsion.
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語言 英文
ISSN 1744-683X
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