期刊論文

學年 102
學期 2
出版(發表)日期 2014-03-04
作品名稱 Direct synthesis of the arylboronic acid analogues of phenylglycine via microwave-assisted four-component Ugi reaction
作品名稱(其他語言)
著者 Lian, Ru-Ching; Lin, Meng-Hsuan; Liao, Pin-Hsuan; Fu, Jia-Jie; Wu, Meng-Ju; Wu, Yang-Chang; Chang, Fang-Rong; Wu, Chin-Chung; Pan, Po-Shen
單位 淡江大學化學學系
出版者 Kidlington: Pergamon Press
著錄名稱、卷期、頁數 Tetrahedron 70(9), pp.1800–1804
摘要 A four-component Ugi reaction (Ugi-4CR) utilizing formylphenyl boronic acids under mild condition was developed for the synthesis of arylboronic acid analogs. The reactions were performed in methanol and accelerated by microwave irradiation, which makes this strategy suitable for constructing boronic-containing chemical libraries. Two of the synthesized analogs were found to have cytotoxic activity against HepG2, MDA-MB231, and A549 cancer cell lines, demonstrating the potential application of this approach in developing novel boron-containing pharmaceuticals.
關鍵字
語言 en
ISSN 0040-4020
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Pan, Po-Shen
審稿制度
國別 GBR
公開徵稿
出版型式 ,紙本
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/98496 )

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