會議論文
| 學年 | 99 |
|---|---|
| 學期 | 1 |
| 發表日期 | 2010-12-18 |
| 作品名稱 | Imputing Missing Values in Microarray Data with Ontology Information |
| 作品名稱（其他語言） | |
| 著者 | Yang, Andy C.; Hsu, Hui-huang; Lu, Ming-da |
| 作品所屬單位 | 淡江大學資訊工程學系 |
| 出版者 | |
| 會議名稱 | Bioinformatics and Biomedicine Workshops (BIBMW), 2010 IEEE International Conference on |
| 會議地點 | Hong Kong |
| 摘要 | Microarray technology is a big step in bioinformatics. Hidden information within the large amounts of data provides scientists with molecular functions or essential biological meanings to study and analyze. However, these data often contain a certain portion of entities that are missing. Several methods to estimate these missing values are developed, but most of them are with disadvantages. In this paper, we propose a novel approach to deal with these missing values based on a practical similarity measurement between gene pairs. Our approach takes gene expression values and gene ontology (GO) information for genes into consideration. We implement our approach on a real microarray dataset and compare its imputation accuracy with other methods. Experimental results show that our approach can estimate missing values in microarray data effectively. |
| 關鍵字 | Microarray;gene ontology;missing value |
| 語言 | en |
| 收錄於 | |
| 會議性質 | 國際 |
| 校內研討會地點 | |
| 研討會時間 | 20101218~20101221 |
| 通訊作者 | |
| 國別 | HKG |
| 公開徵稿 | Y |
| 出版型式 | |
| 出處 | Proceeding of IEEE International Conference on Bioinformatics & Biomedicine Workshops (BIBM 2010), pp.535-540 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/75799 ) |