期刊論文

標題 D-aminoacylase from alcaligenes faecalis possesses novel activities on D-met
學年 82
學期 1
出版(發表)日期 1994/01/01
作品名稱 D-aminoacylase from alcaligenes faecalis possesses novel activities on D-met
作品名稱(其他語言)
著者 Chen, Hao-Ping; Wu, Shih-Hsiung; Wang, Kung-Tsung
單位 淡江大學化學學系
出版者 Kidlington: Pergamon
著錄名稱、卷期、頁數 Bioorganic & Medicinal Chemistry: the Tetrahedron Journal For Research At the Interface of Chemistry and Biology 2(1), pp.1-5
摘要 D-Aminoacylase isolated from Alcaligenes faecalis DA1 has a great potential for future application in D-amino acids production. This paper reports for the first time that D-aminoacylase can reverse the catalysis direction on D-Met and deacylate N-Ac-D-Met-OMe and N-Ac-D-Met-Gly. The results provide important insights regarding the binding and affinity of substrates to the active site of this enzyme. Based on a systematic study of kinetic properties and relative reactivities for a broad range of substrates, a model to elucidate the reaction mechanism is proposed.
關鍵字 d-aminoacylase;enantioselectivity;acylation and deacylation;d-methionine;amino acids
語言 英文
ISSN 0968-0896
期刊性質 國外
收錄於
產學合作
通訊作者 Wu, Shih-Hsiung
審稿制度
國別 英國
公開徵稿
出版型式 紙本