期刊論文
| 學年 | 82 |
|---|---|
| 學期 | 1 |
| 出版（發表）日期 | 1994-01-01 |
| 作品名稱 | D-aminoacylase from alcaligenes faecalis possesses novel activities on D-met |
| 作品名稱（其他語言） | |
| 著者 | Chen, Hao-Ping; Wu, Shih-Hsiung; Wang, Kung-Tsung |
| 單位 | 淡江大學化學學系 |
| 出版者 | Kidlington: Pergamon |
| 著錄名稱、卷期、頁數 | Bioorganic & Medicinal Chemistry: the Tetrahedron Journal For Research At the Interface of Chemistry and Biology 2(1), pp.1-5 |
| 摘要 | D-Aminoacylase isolated from Alcaligenes faecalis DA1 has a great potential for future application in D-amino acids production. This paper reports for the first time that D-aminoacylase can reverse the catalysis direction on D-Met and deacylate N-Ac-D-Met-OMe and N-Ac-D-Met-Gly. The results provide important insights regarding the binding and affinity of substrates to the active site of this enzyme. Based on a systematic study of kinetic properties and relative reactivities for a broad range of substrates, a model to elucidate the reaction mechanism is proposed. |
| 關鍵字 | d-aminoacylase;enantioselectivity;acylation and deacylation;d-methionine;amino acids |
| 語言 | en |
| ISSN | 0968-0896 |
| 期刊性質 | 國外 |
| 收錄於 | |
| 產學合作 | |
| 通訊作者 | Wu, Shih-Hsiung |
| 審稿制度 | |
| 國別 | GBR |
| 公開徵稿 | |
| 出版型式 | 紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/61552 ) |