期刊論文
| 學年 | 96 |
|---|---|
| 學期 | 1 |
| 出版（發表）日期 | 2008-01-01 |
| 作品名稱 | On the Long-Term Fitness of Cells in Periodically Switching Environments |
| 作品名稱（其他語言） | |
| 著者 | Pang, Ning-ning; 曾文哲; Tzeng, Wen-jer |
| 單位 | 淡江大學物理學系 |
| 出版者 | New York: Springer New York LLC |
| 著錄名稱、卷期、頁數 | Bulletin of Mathematical Biology 70(1), pp.210-235 |
| 摘要 | Because all the cell populations are capable of making switches between different genetic expression states in response to the environmental change, Thattai and van Oudenaarden (Genetics 167, 523–530, 2004) have raised a very interesting question: In a constantly fluctuating environment, which type of cell population (heterogeneous or homogeneous) is fitter in the long term? This problem is very important to development and evolution biology. We thus take an extensive analysis about how the cell population evolves in a periodically switching environment either with symmetrical time-span or asymmetrical time-span. A complete picture of the phase diagrams for both cases is obtained. Furthermore, we find that the systems with time-dependent cellular transitions all collapse to the same set of dynamical equations with the modified parameters. Furthermore, we also explain in detail how the fitness problem bears much resemblance to the phenomenon, stochastic resonance, in physical sciences. Our results could be helpful for the biologists to design artificial evolution experiments and unveil the mystery of development and evolution. |
| 關鍵字 | Fitness; Biological switch; Population biology; Evolution; Bifurcation |
| 語言 | en |
| ISSN | 0092-8240 |
| 期刊性質 | 國內 |
| 收錄於 | |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/27862 ) |