期刊論文
| 學年 | 97 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2009-06-01 |
| 作品名稱 | Synthesis of 2-styrylchromones as a novel class of antiproliferative agents targeting carcinoma cells |
| 作品名稱（其他語言） | |
| 著者 | 蕭永政; Shaw, Arthur Y.; Chang, Chun-yi; Liau, Hao-han; Lu, Pei-jung; Chen, Hui-ling; Yang, Chia-ning; Li, Hao-yi |
| 單位 | 淡江大學化學學系 |
| 出版者 | Elsevier |
| 著錄名稱、卷期、頁數 | European Journal of Medicinal Chemistry 44(6), pp.2552-2562 |
| 摘要 | A series of 2-styrylchromone analogs were synthesized and examined for their antiproliferative effects on a panel of carcinoma cells. Among the tested agents, only 4m exhibited a moderate activity with an IC50 value of 28.9 μM against PC-3 cells which indicates the selectivity of PC-3 cells in response to 2-styrylchromones. In addition, 4q demonstrated the most antiproliferative effect with an IC50 value of 4.9 μM against HeLa cells. Flow cytometric analysis and DAPI staining revealed that HeLa cells exposed to 4q as low as 5 μM induced cell death through sub-G1 arrest and DNA fragmentation. Furthermore, CoMFA analysis of tested 2-styrylchromones resulted in a q2 of 0.459 to generate a 3D-QSAR model on BT483 cell line. Together, these results suggest a potential structural optimization and pharmacological study of 2-styrylchromones. |
| 關鍵字 | |
| 語言 | en |
| ISSN | 0223-5234 |
| 期刊性質 | 國外 |
| 收錄於 | |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 否 |
| 國別 | FRA |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/50362 ) |