期刊論文
| 學年 | 97 |
|---|---|
| 學期 | 1 |
| 出版（發表）日期 | 2009-01-01 |
| 作品名稱 | Microwave-Assisted Base-Catalyzed Cyclization and Nucleophilic Substitution of O-Azidobenzanilides to Synthesize 1,2-Disubstituted Indazol-3-ones |
| 作品名稱（其他語言） | |
| 著者 | 蕭永政; Shaw, Arthur Y.; Chen, Yi-ru; Tsai, Chia-hua |
| 單位 | 淡江大學化學學系 |
| 出版者 | Taylor & Francis |
| 著錄名稱、卷期、頁數 | Synthetic Communications 39(15), pp.2647-2663 |
| 摘要 | A series of 1,2-disubstituted indazol-3-ones were synthesized by microwave-assisted base-catalyzed cyclization and nucleophilic substitution of o-azidobenzanilides. Among five tested reaction conditions, the cyclization of o-azidobenzanilides catalyzed by sodium hydride in DMF, sequentially followed by the nucleophilic substitution under microwave irradiation, exhibited the optimal results. Moreover, compared to the counterparts prepared by conventional heat, this method demonstrated a more expeditious and efficient process to establish a diversified 1,2-disubstituted indazol-3-one library for high-throughput biological screening. |
| 關鍵字 | |
| 語言 | en |
| ISSN | 0039-7911 |
| 期刊性質 | 國外 |
| 收錄於 | |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 否 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/50361 ) |