關鍵字查詢 | 類別:期刊論文 | | 關鍵字:Reexamining Dis/Similarity-Based Tests for Rare-Variant Association with Case-Control Samples

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1 106/2 數學系 王彥雯 助理教授 期刊論文 發佈 Reexamining Dis/Similarity-Based Tests for Rare-Variant Association with Case-Control Samples , [106-2] :Reexamining Dis/Similarity-Based Tests for Rare-Variant Association with Case-Control Samples期刊論文Reexamining Dis/Similarity-Based Tests for Rare-Variant Association with Case-Control SamplesCharlotte Wang; Jung-Ying Tzeng; Pei-Zhen Wu; Martin Preisig; Chuhsing Kate HsiaoU-statistics;cross-sample comparison;within-sample comparisonGENETICS 209(1), p.105-113A properly designed distance-based measure can capture informative genetic differences among individuals with different phenotypes and can be used to detect variants responsible for the phenotypes. To detect associated variants, various tests have been designed to contrast genetic dissimilarity or similarity scores of certain subject groups in different ways, among which the most widely used strategy is to quantify the difference between the within-group genetic dissimilarity/similarity (i.e., case-case and control-control similarities) and the between-group dissimilarity/similarity (i.e., case-control similarities). While it has been
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