統計系 謝璦如 助理教授於
Modeling expression quantitative trait loci in data combining ethnic populations
：Modeling expression quantitative trait loci in data combining ethnic populations期刊論文Modeling expression quantitative trait loci in data combining ethnic populationsHsiao CL; Lian IB; Hsieh Ai-Ru; Fann Cathy SJExpression Trait;Allele Frequency Difference;Rejection Probability;HapMap PopulationBMC Bioinformatics 11(1), p.111Background
Combining data from different ethnic populations in a study can increase efficacy of methods designed to identify expression quantitative trait loci (eQTL) compared to analyzing each population independently. In such studies, however, the genetic diversity of minor allele frequencies among populations has rarely been taken into account. Due to the fact that allele frequency diversity and population-level expression differences are present in populations, a consensus regarding the optimal statistical approach for analysis of eQTL in data combining different populations remains inconclusive.
In this report, we explored the applicability of a cons