關鍵字查詢 | 類別:期刊論文 | | 關鍵字:Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model

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序號 學年期 教師動態
1 101/2 化學系 温啟仲 教授 期刊論文 發佈 Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model , [101-2] :Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model期刊論文Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish modelChen, Yau-hung; Wang, Wei-Hua; Wang, Yun-Hsin; Lin, Zi-Yu; Wen, Chi-Chung; Chern, Ching-Yuh淡江大學數學學系;淡江大學化學學系anti-inflammation; chalcone; fin; zebrafishBasel: M D P I AGMolecules 18(2), pp.2052-2060The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our resul
2 101/2 化學系 陳曜鴻 教授 期刊論文 發佈 Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model , [101-2] :Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model期刊論文Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish modelChen, Yau-hung; Wang, Wei-Hua; Wang, Yun-Hsin; Lin, Zi-Yu; Wen, Chi-Chung; Chern, Ching-Yuh淡江大學數學學系;淡江大學化學學系anti-inflammation; chalcone; fin; zebrafishBasel: M D P I AGMolecules 18(2), pp.2052-2060The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our resul
[第一頁][上頁]1[次頁][最末頁]目前在第 1 頁 / 共有 02 筆查詢結果