關鍵字查詢 | 類別:期刊論文 | | 關鍵字:Development of a whole-organism model to screen new compounds for sun protection

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序號 學年期 教師動態
1 97/2 數學系 温啟仲 教授 期刊論文 發佈 Development of a whole-organism model to screen new compounds for sun protection , [97-2] :Development of a whole-organism model to screen new compounds for sun protection期刊論文Development of a whole-organism model to screen new compounds for sun protectionWang, Y.H.; Wen, C.C.; Yang, Z.S.; Cheng, C.C.; Tsai, J.N.; Ku, C.C.; Wu, H.J.; Chen, Y.H.淡江大學數學學系暨研究所New York: Springer New York LLCMarine Biotechnology 11(3), pp.419-29We used zebrafish as a whole-organism model to screen new compounds for sun protection activity. First of all, we designed a series of UVB exposure experiments and recorded the phenotypic changes of zebrafish embryos. Results showed that 100 mJ/cm(2) of UVB given six times separated by 30 min intervals is the best condition. Fin malformation (reduced and/or absent fin) phenotypes are the most evident consequences after exposure to UVB. Each fin was affected by UVB, including pelvic, ventral, caudal, and dorsal fin, but pelvic fin seemed to be the most sensitive target after UVB exposure. We furthermore carried out "prevention" and "treatment" experiments usi
2 97/2 化學系 陳曜鴻 教授 期刊論文 發佈 Development of a whole-organism model to screen new compounds for sun protection , [97-2] :Development of a whole-organism model to screen new compounds for sun protection期刊論文Development of a whole-organism model to screen new compounds for sun protectionWang, Yun-hsin; Wen, Chi-chung; Yang, Zhi-shiang; Cheng, Chien-chung; Tsai, Jen-ning; Ku, Chia-chen; Wu, Hsin-ju; 陳曜鴻; Chen, Yau-hung淡江大學化學學系; 淡江大學數學學系EGCG; Fin; Tea; UV; ZebrafishSpringerMarine Biotechnology 11(3), pp.419-42999學年度陳曜鴻教師升等參考著作 99學年度溫啟仲教師升等參考著作We used zebrafish as a whole-organism model to screen new compounds for sun protection activity. First of all, we designed a series of UVB exposure experiments and recorded the phenotypic changes of zebrafish embryos. Results showed that 100 mJ/cm2 of UVB given six times separated by 30 min intervals is the best condition. Fin malformation (reduced and/or absent fin) phenotypes are the most evident consequences after exposure to UVB. Each fin was affected by UVB, including pelvic, ventral, caudal, and dorsal fin, but pelvic fin seemed to be the most sensitive target af
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