關鍵字查詢 | 類別:期刊論文 | | 關鍵字:Caffeine treatment disturbs the angiogenesis of zebrafish embryos

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序號 學年期 教師動態
1 101/1 數學系 温啟仲 教授 期刊論文 發佈 Caffeine treatment disturbs the angiogenesis of zebrafish embryos , [101-1] :Caffeine treatment disturbs the angiogenesis of zebrafish embryos期刊論文Caffeine treatment disturbs the angiogenesis of zebrafish embryosYeh, C.H.; Liao, Y.F.; Chang, C.Y.; Tsai, J.N.; Wang, Y.H.; Cheng, C.C.; Wen, C.C.; Chen, Y.H.淡江大學數學學系暨研究所New York: Informa HealthcareDrug and Chemical Toxicology 35(4), pp.361-5Caffeine is a widely consumed substance that occurs in numerous dietary sources, but teratogenic effects of caffeine intake during embryonic development are still not clear. In the present study, we used the zebrafish as a model to assess caffeine-induced toxicity on embryonic vascular development. A green fluorescent vascular endothelium transgenic line, Tg(fli1:egfp), was utilized for the sensitive detection of vascular development, including vasculo- and angiogenesis. Caffeine-treated embryos showed no defects in vasculogenesis, but revealed dose-dependent (250-350 ppm) developmental defects in intersegmental vessels, dorsal longitudinal anastomotic vessels, and subintestinal
2 101/1 化學系 陳曜鴻 教授 期刊論文 發佈 Caffeine treatment disturbs the angiogenesis of zebrafish embryos , [101-1] :Caffeine treatment disturbs the angiogenesis of zebrafish embryos期刊論文Caffeine treatment disturbs the angiogenesis of zebrafish embryosYeh, Chien-Hung; Liao, Yun-Feng; Chang, Chao-Yuan; Tsai, Jen-Ning; Wang, Yun-Hsin; Cheng, Chien-Chung; Wen, Chi-Chung; Chen, Yau-Hung淡江大學生命科學研究所; 淡江大學化學學系Angiogenesis;caffeine;fluorescent protein;transgenic fish;zebrafishNew York: Informa HealthcareDrug and Chemical Toxicology 35(4), pp.361-365Caffeine is a widely consumed substance that occurs in numerous dietary sources, but teratogenic effects of caffeine intake during embryonic development are still not clear. In the present study, we used the zebrafish as a model to assess caffeine-induced toxicity on embryonic vascular development. A green fluorescent vascular endothelium transgenic line, Tg(fli1:egfp), was utilized for the sensitive detection of vascular development, including vasculo- and angiogenesis. Caffeine-treated embryos showed no defects in vasculogenesis, but revealed dose-dependent (250-
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