關鍵字查詢 | 類別:期刊論文 | | 關鍵字:Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo

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序號 學年期 教師動態
1 104/2 尖端材料科學學程 陳曜鴻 教授 期刊論文 發佈 Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo , [104-2] :Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo期刊論文Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryoYan, De-Yue; Ni, Lin-Kai; Chen, Ho-Lun; Chen, Li-Chou; Chen, Yau-Hung; Cheng, Chien-ChungLiposome;Resveratrol;Norcantharidin;Drug delivery;Tadpole structureBioorganic & Medicinal Chemistry Letters 26(3), pp.774-777Direct coupling of a hydrophobic drug and a hydrophilic natural product via an ester bond produced an amphiphilic adduct that formed liposomes. Liposomes of resveratrol–norcantharidin adduct are capable of forming a tadpole-like nanoparticle and exhibited high toxicity in zebrafish embryos to give the better transportation and the effective concentration into cells. Using fluorescent chromophore showed the liposome in the stomach and intestinal villi rather than in the skin and muscle. This result may provide an insight into the mechanism of action of traditional Chinese medici
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