關鍵字查詢 | 類別:期刊論文 | | 關鍵字:A non-threshold region-specific method for detecting rare variants in complex diseases

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1 106/1 統計系 謝璦如 助理教授 期刊論文 發佈 A non-threshold region-specific method for detecting rare variants in complex diseases , [106-1] :A non-threshold region-specific method for detecting rare variants in complex diseases期刊論文A non-threshold region-specific method for detecting rare variants in complex diseasesHsieh Ai-Ru, Dao-Peng Chen, Amrita Sengupta Chattopadhyay, Ying-Ju Li, Chien-Ching Chang and Cathy SJ FannPLoS One. 12(11), p.0188566A region-specific method, NTR (non-threshold rare) variant detection method, was developed—it does not use the threshold for defining rare variants and accounts for directions of effects. NTR also considers linkage disequilibrium within the region and accommodates common and rare variants simultaneously. NTR weighs variants according to minor allele frequency and odds ratio to combine the effects of common and rare variants on disease occurrence into a single score and provides a test statistic to assess the significance of the score. In the simulations, under different effect sizes, the power of NTR increased as the effect size increased, and the type I error of our method was cont
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