教師資料查詢 | 類別: 期刊論文 | 教師: 廖康伶 KANG-LING LIAO (瀏覽個人網頁)

標題:Dose-duration reciprocity for G protein activation: modulation of kinase to substrate ratio alters cell signaling
學年106
學期1
出版(發表)日期2017/12/15
作品名稱Dose-duration reciprocity for G protein activation: modulation of kinase to substrate ratio alters cell signaling
作品名稱(其他語言)
著者Kang-Ling Liao; Charles E. Melvin; Rosangela Sozzani; Roger D. Jones; Timothy C. Elston; Alan M. Jones
單位
出版者
著錄名稱、卷期、頁數PLoS ONE
摘要In animal cells, activation of heterotrimeric G protein signaling generally occurs when the system’s cognate signal exceeds a threshold, whereas in plant cells, both the amount and the exposure time of at least one signal, D-glucose, are used toward activation. This unusual signaling property called Dose-Duration Reciprocity, first elucidated in the genetic model Arabidopsis thaliana, is achieved by a complex that is comprised of a 7-transmembrane REGULATOR OF G SIGNALING (RGS) protein (AtRGS1), a Gα subunit that binds and hydrolyzes nucleotide, a Gβγ dimer, and three WITH NO LYSINE (WNK) kinases. D-glucose is one of several signals such as salt and pathogen-derived molecular patterns that operates through this protein complex to activate G protein signaling by WNK kinase transphosphorylation of AtRGS1. Because WNK kinases compete for the same substrate, AtRGS1, we hypothesize that activation is sensitive to the AtRGS1 amount and that modulation of the AtRGS1 pool affects the response to the stimulant. Mathematical simulation revealed that the ratio of AtRGS1 to the kinase affects system sensitivity to D-glucose, and therefore illustrates how modulation of the cellular AtRGS1 level is a means to change signal induced activation. AtRGS1 levels change under tested conditions that mimic physiological conditions therefore, we propose is a previously-unknown mechanism by which plants react to changes in their environment.
關鍵字Arabidopsis; Regulator of G Signaling; WNK kinase; heterotrimeric G protein; 15 endocytosis; glucose sensor; salt response
語言英文
ISSN
期刊性質國外
收錄於SCI;
產學合作
通訊作者Alan M. Jones
審稿制度
國別美國
公開徵稿
出版型式,電子版,紙本
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