教師資料查詢 | 類別: 期刊論文 | 教師: 廖康伶 KANG-LING LIAO (瀏覽個人網頁)

標題:The role of CD200-CD200R in tumor immune evasion
學年101
學期1
出版(發表)日期2012/09/01
作品名稱The role of CD200-CD200R in tumor immune evasion
作品名稱(其他語言)
著者Kang-Ling Liao, Xue-Feng Bai, and Avner Friedman
單位
出版者
著錄名稱、卷期、頁數Journal of Theoretical Biology, No. 328, 65-76.
摘要CD200 is a cell membrane protein that interacts with CD200 receptor (CD200R) of myeloid lineage cells. During tumor initiation and progression, CD200-positive tumor cells can interact with M1 and M2 macrophages through CD200-CD200R-compex, and downregulate IL-10 and IL-12 productions secreted primarily by M2 and M1 macrophages, respectively. In the tumor microenvironment, IL-10 inhibits the activation of cytotoxic T lymphocytes (CTL), while IL-12 enhances CTL activation. In this paper, we used a system approach to determine the combined effect of CD200-CD200R interaction on tumor proliferation by developing a mathematical model. We demonstrate that blocking CD200 on tumor cells may have opposite effects on tumor proliferation depending on the "affinity" of the macrophages to form the CD200-CD200R-complex with tumor cells. Our results help understanding the complexities of tumor microenvironment.
關鍵字Tumor cells; Macrophages; CD200R; Interleukin 10; Interleukin 12
語言英文(美國)
ISSN
期刊性質國外
收錄於SCI;
產學合作
通訊作者8. Kang-Ling Liao
審稿制度
國別美國
公開徵稿
出版型式,電子版
相關連結
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