教師資料查詢 | 類別: 期刊論文 | 教師: 廖康伶 KANG-LING LIAO (瀏覽個人網頁)

標題:Mathematical modeling of Interleukin 35 promoting tumor growth and angiogenesis
學年103
學期1
出版(發表)日期2014/10/30
作品名稱Mathematical modeling of Interleukin 35 promoting tumor growth and angiogenesis
作品名稱(其他語言)
著者Kang-Ling Liao, Xue-Feng Bai, and Avner Friedman
單位
出版者
著錄名稱、卷期、頁數PLoS One. 2014 Oct 30;9(10):e110126
摘要Interleukin-35 (IL-35), a cytokine from the Interleukin-12 cytokine family, has been considered as an anti-inflammatory cytokine which promotes tumor progression and tumor immune evasion. It has also been demonstrated that IL-35 is secreted by regulatory T cells. Recent mouse experiments have shown that IL-35 produced by cancer cells promotes tumor growth via enhancing myeloid cell accumulation and angiogenesis, and reducing the infiltration of activated CD8 T cells into tumor microenvironment. In the present paper we develop a mathematical model based on these experimental results. We include in the model an anti-IL-35 drug as treatment. The extended model (with drug) is used to design protocols of anti-IL-35 injections for treatment of cancer. We find that with a fixed total amount of drug, continuous injection has better efficacy than intermittent injections in reducing the tumor load while the treatment is ongoing. We also find that the percentage of tumor reduction under anti-IL-35 treatment improves when the production of IL-35 by cancer is increased.
關鍵字
語言英文(美國)
ISSN
期刊性質國外
收錄於SCI;
產學合作
通訊作者Kang-Ling Liao
審稿制度
國別美國
公開徵稿
出版型式,電子版
相關連結
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