教師資料查詢 | 類別: 期刊論文 | 教師: 廖康伶 KANG-LING LIAO (瀏覽個人網頁)

標題:The role of the cytokines IL-27 and IL-35 in cancer
學年104
學期1
出版(發表)日期2015/12/01
作品名稱The role of the cytokines IL-27 and IL-35 in cancer
作品名稱(其他語言)
著者Avner Friedman and Kang-Ling Liao
單位
出版者
著錄名稱、卷期、頁數Math Biosci Eng. 2015 Dec;12(6):1203-17.
摘要The cancer-immune interaction is a fast growing field of research in biology, where the goal is to harness the immune system to fight cancer more effectively. In the present paper we review recent work of the interaction between T cells and cancer. CD8+ T cells are activated by IL-27 cytokine and they kill tumor cells. Regulatory T cells produce IL-35 which promotes cancer cells by enhancing angiogenesis, and inhibit CD8+ T cells via TGF-β production. Hence injections of IL-27 and anti-IL-35 are both potentially anti-tumor drugs. The models presented here are based on experimental mouse experiments, and their simulations agree with these experiments. The models are used to suggest effective schedules for drug treatment.
關鍵字
語言英文(美國)
ISSN
期刊性質國外
收錄於SCI;
產學合作
通訊作者Avner Friedman
審稿制度
國別美國
公開徵稿
出版型式,電子版
相關連結
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