教師資料查詢 | 類別: 期刊論文 | 教師: 王三郎 WANG SAN-LANG (瀏覽個人網頁)

標題:Conversion of shrimp heads to α-glucosidase inhibitors via co-culture of Bacillus mycoides TKU040 and Rhizobium sp. TKU041
學年107
學期1
出版(發表)日期2018/08/01
作品名稱Conversion of shrimp heads to α-glucosidase inhibitors via co-culture of Bacillus mycoides TKU040 and Rhizobium sp. TKU041
作品名稱(其他語言)
著者Hsu C.H.; Nguyen V.B.; Nguyen A.D.; Wang San-Lang
單位
出版者
著錄名稱、卷期、頁數Research on Chemical Intermediates 44(8), p.4597–4607
摘要Alpha-glucosidase inhibitors (aGIs) have potential use as antidiabetic drugs for the treatment of type II diabetes. Most aGIs place a burden on the liver and cause gastrointestinal distress, therefore the development of new aGIs has become very important. In this study, we investigated the production of aGIs by the co-culture of Bacillus mycoides TKU040 and Rhizobium sp. TKU041 using shrimp head powder (SHP) as the sole source of carbon and nitrogen. After fermentation in 50 mL of 1% SHP-containing medium (0.1% K2HPO4 and 0.05% MgSO4·7H2O, pH 9.2) at 37 °C for 4 days, the maximum productivity of aGIs (143 U/mL) was reached. The IC50 of the aGIs produced in the culture supernatant was 3 mg/mL. The aGI activity was only 60% after treatment at pH 3 for 30 min; this increased to 140% after treatment at pH 11 for 30 min. The aGI activity remained at 60% after treatment at 60 °C for 30 min.
關鍵字diabetes;glucosidase inhibitors;Bacillus;Rhizobium
語言英文
ISSN0922-6168;1568-5675
期刊性質國外
收錄於SCI;
產學合作
通訊作者Wang San-Lang
審稿制度
國別美國
公開徵稿
出版型式,電子版
相關連結
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