教師資料查詢 | 類別: 期刊論文 | 教師: 謝仁傑 Hsieh, Jen-chieh (瀏覽個人網頁)

標題:Cobalt-Catalyzed Dual Annulation of o-Halobenzaldimine with Alkyne: A Powerful Route toward Bioactive Indenoisoquinolinones
學年103
學期2
出版(發表)日期2015/06/22
作品名稱Cobalt-Catalyzed Dual Annulation of o-Halobenzaldimine with Alkyne: A Powerful Route toward Bioactive Indenoisoquinolinones
作品名稱(其他語言)
著者謝仁傑
單位
出版者Wiley
著錄名稱、卷期、頁數Chemistry 21(26), p.9544–9549
摘要A cobalt-catalyzed dual annulation reaction for the synthesis of variously substituted indenoisoquinolinones from 2-bromobenzaldehydes, amines, and methyl 2-(ethynyl)benzoates has been developed. This method could also be applied to the synthesis of an array of highly functionalized bioactive indenoisoquinolinones and their derivatives. A possible mechanism of the cobalt catalysis is proposed, involving imine formation from bromobenzaldehyde and the amine, followed by a series of oxidative addition, alkyne insertion, cyclization reactions, and carbon-carbon double-bond migration. The regioselective alkyne insertion plays an important role for the success of the second annulation.
關鍵字azametallacycles;cobalt;indenes;isoquinoline;zinc
語言英文
ISSN0972-8376
期刊性質國外
收錄於SCI;
產學合作
通訊作者謝仁傑
審稿制度
國別德國
公開徵稿
出版型式,電子版,紙本
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