教師資料查詢 | 類別: 期刊論文 | 教師: 李世元 ADAM SHIH-YUAN LEE (瀏覽個人網頁)

標題:Inhibitors of 25-hydroxyvitamin D3-1α-hydroxylase: Thiavitamin D analogs and biological evaluation
學年85
學期2
出版(發表)日期1997/05/01
作品名稱Inhibitors of 25-hydroxyvitamin D3-1α-hydroxylase: Thiavitamin D analogs and biological evaluation
作品名稱(其他語言)
著者李世元; Lee, Adam Shih-yuan; Muralidharan, K. Raman; Rowland-Goldsmith, Melissa; Park, Gyoosoon; Norman, Anthony W.; Henry, Helen L.;Okamura, William H.
單位淡江大學化學學系
出版者Elsevier
著錄名稱、卷期、頁數Journal of steroid biochemistry and molecular biology 62(1), pp.73-78
摘要Six A-ring analogs of 1α,25-dihydroxyvitamin D3 (1, 1α,25-(OH)2-D3) 3-deoxy-3-thia-1α,25-(OH)2-D3 (3), 3-deoxy-3-thia-1α,25-(OH)2-D3-3α-oxide (6), 3-deoxy-3-thia-1α,25-(OH)2-D3-3β-oxide (7) and the 5,6-trans counterparts 5, 8, and 9, respectively—were tested for their ability to inhibit 25-hydroxy-D3-1α-hydroxylase (1-OH-ase) in vitro in mitochondria isolated from kidneys of vitamin D deficient chicks. The six analogs were also evaluated in terms of their ability to bind to the chicken intestinal nuclear receptor (VDR) in comparison to the natural hormone 1α,25-(OH)2-D3. Analog 7 is not only the best inhibitor of the 1-OH-ase but it also binds effectively to the chick intestinal receptor. It is established that vitamin D analogs must have a 1α oxygen group for effective inhibition of the 1-OH-ase. This functional group is also needed for effective binding to the chick intestinal VDR.
關鍵字
語言英文
ISSN0960-0760
期刊性質國內
收錄於
產學合作
通訊作者
審稿制度
國別中華民國
公開徵稿
出版型式,電子版
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