教師資料查詢 | 類別: 期刊論文 | 教師: 李世元 ADAM SHIH-YUAN LEE (瀏覽個人網頁)

標題:A novel reusable nanomechanics based protein biosensor with electrical manipulation
學年93
學期1
出版(發表)日期2005/01/01
作品名稱A novel reusable nanomechanics based protein biosensor with electrical manipulation
作品名稱(其他語言)
著者李世元; Lee, Adam Shih-yuan; Hwang, R.-Z.; Huang, L.-S.; Chang, H.-S.; Wu, C.-W.; Tien, H.-C.; Lin, S.
單位淡江大學化學學系
出版者Institute of Electrical and Electronics Engineers (IEEE)
著錄名稱、卷期、頁數Micro Electro Mechanical Systems, 2005. MEMS 2005. 18th IEEE International Conference on, pp.798-801
摘要A novel reusable biosensor of label-free biomolecular recognition based on the nanomechanics transduction in a micro-fabricated cantilever has been developed. The nanomechanics-based immunoassay biosensor was proven to be repeatedly used with desorption of the pre-bound antigen-antibody by an in-situ alternative electrical field. This new approach of electric manipulation in separating the antigen out of the antibody in a buffer fluid environment was confirmed in nanomechanics-based immunoassay biosensor in which a conventional desorption is long used with high concentrated acid solution in a range of pH 2/spl sim/3. The potential benefit of the electrical means over a conventional pre-bound antigen-antibody desorption of strong acid solution is to maintain long-standing protein activity in multiple uses such that the micro biosensor is reliable and reproducible in every detection. The complete sensing history from a monolayer of biolinker, to antibody and antigen is also first demonstrated in nanomechanics-based immunoassay.
關鍵字Proteins;Biosensors;Immune system;Silicon;Sea surface;Stress;Nanoscale devices;Gold;Nickel;Electrodes
語言英文(美國)
ISSN1084-6999
期刊性質國外
收錄於
產學合作
通訊作者
審稿制度
國別美國
公開徵稿
出版型式,紙本
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