期刊論文
| 學年 | 112 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2024-02-19 |
| 作品名稱 | The angiogenesis-modulating effects of coumarin-derivatives |
| 作品名稱（其他語言） | |
| 著者 | Huang, Han-ting; Huang, Ching-yuan; Lee, Chih-jou; Sun, Bo-jie; Wen, Chi-chung; Wang, Yun-hsin; Chen, Yau-hung |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Comparative Biochemistry and Physiology Part C 278, 109862 |
| 摘要 | Coumarin is a natural compound that is rich in plants. Coumarin and its derivates were reported to have many biological activities, such as anti-bacterial, anti-tumor, and anti-coagulation. In this study, we examined the angiogenic modulating activities of six previously synthesized coumarin derivatives (Compound #1-#6) in zebrafish embryos and further confirmed them in a chick model. According to the survival rate in a zebrafish model, Compound #1 (100 %), #2 (82.5–100 %), and #4 (100 %) showed much less toxicity than Compound #3 (19.2–100 %), #5 (0–100 %), and #6 (0–100 %). Using a green blood vessel fluorescent transgenic fish Tg(fli1:egfp) to record the angiogenesis-modulating effects of Compound #1, #2, and #4, we found that Compound #2 had the highest effects in interfering intersegmental vessel growth, subintestinal vein growth, and caudal vein plexus remodeling. Chick chorioallantoic membrane (CAM) assay also showed that Compound #2 exposure led to a reduction of blood vessel growth. Real-time PCR experiments revealed that Compound #2 significantly changed the expression of vascular growth-related genes flt1, cdh5, and nrp1a in zebrafish. Based on our data from zebrafish and chick models, a new coumarin-derivative (Compound #2) possesses anti-angiogenic activity with low toxicity, but further investigation in mammal models is asked to confirm our findings. |
| 關鍵字 | |
| 語言 | en |
| ISSN | 1878-1659 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 是 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/125639 ) |