期刊論文
| 學年 | 108 |
|---|---|
| 學期 | 1 |
| 出版（發表）日期 | 2019-10-15 |
| 作品名稱 | New indications of potential rat intestinal α-glucosidase inhibition by Syzygium zeylanicum (L.) and its hypoglycemic effect in mice |
| 作品名稱（其他語言） | |
| 著者 | Van Bon Nguyen; San-Lang Wang; Thi Hanh Nguyen; Chien Thang Doan; Thi Ngoc Tran; Yao-Haur Kuo; Quang Vinh Nguyen; Anh Dzung Nguyen |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Research on Chemical Intermediates |
| 摘要 | Natural α-glucosidase inhibitors (aGIs) have been considered efective agents for type 2 diabetes management. In this study, Syzygium zeylanicum (L.) (SZL), a medicinal plant that grows wild in the Central Highlands of Vietnam, was reported for the frst time to have potential anti-diabetic properties. The methanol extract of SZL possessed potent rat intestinal α-glucosidase inhibitory activity with low IC50 and great maximum inhibition values of 109 µg/mL and 100%, respectively. This was higher activity than acarbose, an anti-diabetic drug with IC50 and maximum inhibition values of 540 µg/ml and 80%, respectively. In specifc inhibition tests, the herbal extract demonstrated strong inhibition against α-glucosidases from Saccharomyces cerevisiae and Bacillus stearothermophilus with small IC50 values of 0.18 and 0.31 µg/mL, respectively. SZL extract also demonstrated potent inhibition against porcine pancreatic α-amylase with maximum inhibition and IC50 values of 99.2% and 3.7 µg/mL, respectively. SZL displayed high thermal and pH stability, with respective activities of 87% and 100–140% when treated at 100 °C or over a wide pH range of 2–13. The herbal extract was further investigated for its efcacy using ICR mice as the animal model. At a dose of 100 mg/kg BW, SZL signifcantly reduced blood glucose in mice and no signs of diarrhea were observed. The results from this study suggest that SZL, a potent and natural source of aGIs, may be a good candidate for the treatment of type 2 diabetes. |
| 關鍵字 | α-Glucosidase inhibitors;Diabetes;Syzygium zeylanicum (L.);Hypoglycemic efect |
| 語言 | en |
| ISSN | 0922-6168 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | San-Lang Wang |
| 審稿制度 | 是 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/117472 ) |