期刊論文
| 學年 | 107 |
|---|---|
| 學期 | 1 |
| 出版（發表）日期 | 2018-12-29 |
| 作品名稱 | Low Diastolic Blood Pressure and High Blood Pressure Variability are Risk Factors for Cognitive Decline in Elderly Adults: A Case-Control Study |
| 作品名稱（其他語言） | |
| 著者 | Chia-Chi Chen; Jia-Fu Lee; Yu-Lin Ko; Chun-Te Lee; Yue-Cune Chang |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Neuropsychiatry (London) 8(6), p.1986-1992 |
| 摘要 | Background This study investigated the association between visit-to-visit blood pressure (BP) variability and cognitive decline in elderly adults over a 4-month period. Methods All 94 elderly volunteers were recruited from a community center. Mini-Mental Status Examination (MMSE) and Clinical Dementia Rating (CDR) questionnaires were administered during the initial assessment and at 4 months after the service. The BP at each visit and the visit-to-visit BP variability were measured for 4 consecutive months. Results The middle-stage/moderate cognitive impairment (MMSE scores ≤ 21) group exhibited significantly lower minimum diastolic BP and higher diastolic coefficient of variation values than did the mild/no cognitive impairment (MMSE scores >21) group did. After adjustment for the effects of age, the minimum diastolic BP was significantly and positively associated with the MMSE scores (P=0.033). To further evaluate the effects of low diastolic BP (LDBP) on cognitive function, we compared the initial and 4-month MMSE scores between the LDBP group (minimum diastolic BP ≤ 50 mmHg) and the control group (minimum diastolic BP>50 mmHg). We divided the volunteers into the following 4 groups: (1) hypertension history with LDBP (HT-c-LDBP), (2) hypertension history without LDBP (HT-s-LDBP), (3) no hypertension history without LDBP (nHT-s-LDBP), and (4) no hypertension history with LDBP (nHT-c-LDBP). The cognitive function differed significantly among the four groups (MMSE scores: HT-c-LDBP=21.62 ± 2.87; HT-s-LDBP=25.20 ± 2.78; nHT-s-LDBP=26.12 ± 3.65; and nHT-c-LDBP=23.27 ± 3.16). Compared to the nHT-s-LDBP group, the data showed that the HT-c-LDBP group exhibited significantly worse cognitive function, followed by the nHT-c-LDBP group. Conclusions LDBP and high diastolic BP variability are risk factors for cognitive function decline in elderly adults. |
| 關鍵字 | Diastolic blood pressure;Blood pressure variability;Cognitive decline;Elderly adults |
| 語言 | en_US |
| ISSN | 1758-2008 |
| 期刊性質 | 國外 |
| 收錄於 | |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 是 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | ,電子版,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/115984 ) |