期刊論文

標題 Reclamation of shrimp heads for the production of α-glucosidase inhibitors by Staphylococcus sp. TKU043
學年 107
學期 1
出版(發表)日期 2018/08/01
作品名稱 Reclamation of shrimp heads for the production of α-glucosidase inhibitors by Staphylococcus sp. TKU043
作品名稱(其他語言)
著者 San-Lang Wang; Yu-Cheng Su; Van Bon Nguyen; Anh Dzung Nguyen
單位
出版者
著錄名稱、卷期、頁數 Research on Chemical Intermediates 44(8), p.4929–4937
摘要 Alpha-glucosidase inhibitors (aGIs) have received much attention due to their important use in treating diabetes mellitus. Although some synthetic aGIs have been available for a long time, they often cause various unexpected side effects. The purpose of this study was to reclaim shrimp heads for the production of aGIs via bacteria. Staphylococcus sp. TKU043, a bacterium strain isolated from Taiwanese soil produced aGIs in a shrimp-head-containing medium. Maximum productivity of aGIs (1457 U/mL) was found after cultivation in 1% shrimp head powder medium for 3 days. The aGI partially purified by column chromatography showed thermal instability, and presumably was a proteinous material. The inhibitor mode of this aGI was determined to be a mixed inhibition mode (non-competitive–uncompetitive inhibition).
關鍵字 Chitin;Shrimp head;α-glucosidase inhibitor;Staphylococcus
語言 英文
ISSN 0922-6168
期刊性質 國外
收錄於 SCI;
產學合作
通訊作者 Wang SL; Su YC, Nguyen VB; Nguyen AD
審稿制度
國別 美國
公開徵稿
出版型式 ,電子版