期刊論文
| 學年 | 106 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2018-02-01 |
| 作品名稱 | New novel α–glucosidase inhibitors produced by microbial conversion |
| 作品名稱（其他語言） | |
| 著者 | Nguyen Van Bon, Wang San-Lang |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Process Biochemistry 65, p.228-232 |
| 摘要 | Fermented Nutrient Broth (FNB) was found to be a potential source of antidiabetic drugs in the previous report. Thus, FNB was employed to isolate the active compounds in this study. Novel 5 α-glucosidase inhibitors (aGIs) were isolated from FNB and identified as: (1) Adenine, (2) 3-hydroxyproline, (3) Creatinine, (4) Nicotinic acid, and (5) Niacinamide. Notably, these inhibitors were found as new microbial aGIs, non-sugar-based moiety aGIs. Of these inhibitors, compounds 2 and 4 showed activity against rat α-glucosidase equal to, or stronger than, that of acarbose, with the IC50 values of 100, 67, and 115 μg/mL, respectively. These results contributed to enriching the current poor novel microbial aGIs, and also confirmed that FNB shows promising utilization for diabetes and obesity treatments or health foods due to their containing efficient mammalian aGIs. |
| 關鍵字 | α–glucosidase inhibitor;Paenibacillus sp.;Diabetes;Microbial conversion |
| 語言 | en |
| ISSN | 1359-5113 |
| 期刊性質 | 國外 |
| 收錄於 | SCI EI |
| 產學合作 | |
| 通訊作者 | WANG San-Lang |
| 審稿制度 | 是 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/112696 ) |