期刊論文
| 學年 | 106 |
|---|---|
| 學期 | 1 |
| 出版（發表）日期 | 2017-11-07 |
| 作品名稱 | Reclamation of marine chitinous materials for the production of α-glucosdase inhibitors via microbial conversion |
| 作品名稱（其他語言） | |
| 著者 | Van Bon Nguyen; San-Lang Wang |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Marine Drugs 15(11), p.350(11 pages) |
| 摘要 | Six kinds of chitinous materials have been used as sole carbon/nitrogen (C/N) sources for producing α-glucosidase inhibitors (aGI) by Paenibacillus sp. TKU042. The aGI productivity was found to be highest in the culture supernatants using demineralized crab shell powder (deCSP) and demineralized shrimp shell powder (deSSP) as the C/N source. The half maximal inhibitory concentration (IC50) and maximum aGI activity of fermented deCSP (38 µg/mL, 98%), deSSP (108 µg/mL, 89%), squid pen powder (SPP) (422 µg/mL, 98%), and shrimp head powder (SHP) (455 µg/mL, 92%) were compared with those of fermented nutrient broth (FNB) (81 µg/mL, 93%) and acarbose (1095 µg/mL, 74%), a commercial antidiabetic drug. The result of the protein/chitin ratio on aGI production showed that the optimal ratio was 0.2/1. Fermented deCSP showed lower IC50 and higher maximum inhibitory activity than those of acarbose against rat intestinal α-glucosidase. |
| 關鍵字 | chitin;crab shells;α-glucosidase inhibitor;Paenibacillus;diabetes |
| 語言 | en |
| ISSN | 1660-3397 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | San-Lang Wang |
| 審稿制度 | 否 |
| 國別 | SWE |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/112049 ) |