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標題
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Conversion of shrimp heads to α-glucosidase inhibitors via co-culture of Bacillus mycoides TKU040 and Rhizobium sp. TKU041 |
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學年
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107 |
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學期
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1 |
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出版（發表）日期
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2018/08/01 |
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作品名稱
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Conversion of shrimp heads to α-glucosidase inhibitors via co-culture of Bacillus mycoides TKU040 and Rhizobium sp. TKU041 |
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作品名稱（其他語言）
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著者
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Hsu C.H.; Nguyen V.B.; Nguyen A.D.; Wang San-Lang |
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單位
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出版者
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著錄名稱、卷期、頁數
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Research on Chemical Intermediates 44(8), p.4597–4607 |
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摘要
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Alpha-glucosidase inhibitors (aGIs) have potential use as antidiabetic drugs for the treatment of type II diabetes. Most aGIs place a burden on the liver and cause gastrointestinal distress, therefore the development of new aGIs has become very important. In this study, we investigated the production of aGIs by the co-culture of Bacillus mycoides TKU040 and Rhizobium sp. TKU041 using shrimp head powder (SHP) as the sole source of carbon and nitrogen. After fermentation in 50 mL of 1% SHP-containing medium (0.1% K2HPO4 and 0.05% MgSO4·7H2O, pH 9.2) at 37 °C for 4 days, the maximum productivity of aGIs (143 U/mL) was reached. The IC50 of the aGIs produced in the culture supernatant was 3 mg/mL. The aGI activity was only 60% after treatment at pH 3 for 30 min; this increased to 140% after treatment at pH 11 for 30 min. The aGI activity remained at 60% after treatment at 60 °C for 30 min. |
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關鍵字
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diabetes;glucosidase inhibitors;Bacillus;Rhizobium |
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語言
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英文 |
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ISSN
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0922-6168;1568-5675 |
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期刊性質
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國外 |
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收錄於
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SCI; |
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產學合作
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通訊作者
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Wang San-Lang |
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審稿制度
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是 |
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國別
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美國 |
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公開徵稿
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出版型式
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,電子版 |