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標題
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Porcine pancreatic α-amylase inhibitors from Euonymus laxiflorus Champ |
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學年
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105 |
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學期
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1 |
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出版（發表）日期
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2017/01/01 |
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作品名稱
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Porcine pancreatic α-amylase inhibitors from Euonymus laxiflorus Champ |
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作品名稱（其他語言）
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著者
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Nguyen, Van Bon; Nguyen, Anh Dzung; Nguyen, Quang Vinh; Wang, San-Lang |
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單位
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出版者
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著錄名稱、卷期、頁數
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Research on Chemical Intermediates 43(1), p.259–269 |
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摘要
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Twenty-six samples of indigenous medicinal plants were collected in Dak Lak Province of Vietnam and evaluated for α-amylase inhibitory activity. Of these samples, trunk bark extract from Euonymus laxiflorus Champ. (ELC extract) showed the greatest α-amylase inhibitory activity with the smallest 50 % inhibitory concentration (IC50) of 6.6 ± 0.6 µg/mL against porcine pancreatic α-amylase. This extract possessed strong inhibitory activity against human saliva α-amylase and slightly lower activity against Bacillus subtilis α-amylase, with IC50 values of 4.2 ± 0.2 and 27.8 ± 1.8 µg/mL, respectively. ELC extract was found to be strongly thermostable, retaining 72–100 % relative activity even after heating at 100 °C for 5 min to 2 h. This extract was also stable at various pH values. These results suggest that ELC extract may be a good candidate for treatment of non-insulin-dependent diabetes mellitus (NIDDM) and obesity. |
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關鍵字
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α-Amylase inhibitors;Diabetes;Obesity;Medicinal plants;Euonymus laxiflorus;Champ.;Dak Lak |
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語言
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英文 |
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ISSN
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0922-6168;1568-5675 |
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期刊性質
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國外 |
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收錄於
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SCI; |
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產學合作
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通訊作者
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Wang, San-Lang |
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審稿制度
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是 |
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國別
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荷蘭 |
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公開徵稿
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出版型式
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,電子版 |