標題
|
Porcine pancreatic α-amylase inhibitors from Euonymus laxiflorus Champ |
學年
|
105 |
學期
|
1 |
出版(發表)日期
|
2017/01/01 |
作品名稱
|
Porcine pancreatic α-amylase inhibitors from Euonymus laxiflorus Champ |
作品名稱(其他語言)
|
|
著者
|
Nguyen, Van Bon; Nguyen, Anh Dzung; Nguyen, Quang Vinh; Wang, San-Lang |
單位
|
|
出版者
|
|
著錄名稱、卷期、頁數
|
Research on Chemical Intermediates 43(1), p.259–269 |
摘要
|
Twenty-six samples of indigenous medicinal plants were collected in Dak Lak Province of Vietnam and evaluated for α-amylase inhibitory activity. Of these samples, trunk bark extract from Euonymus laxiflorus Champ. (ELC extract) showed the greatest α-amylase inhibitory activity with the smallest 50 % inhibitory concentration (IC50) of 6.6 ± 0.6 µg/mL against porcine pancreatic α-amylase. This extract possessed strong inhibitory activity against human saliva α-amylase and slightly lower activity against Bacillus subtilis α-amylase, with IC50 values of 4.2 ± 0.2 and 27.8 ± 1.8 µg/mL, respectively. ELC extract was found to be strongly thermostable, retaining 72–100 % relative activity even after heating at 100 °C for 5 min to 2 h. This extract was also stable at various pH values. These results suggest that ELC extract may be a good candidate for treatment of non-insulin-dependent diabetes mellitus (NIDDM) and obesity. |
關鍵字
|
α-Amylase inhibitors;Diabetes;Obesity;Medicinal plants;Euonymus laxiflorus;Champ.;Dak Lak |
語言
|
英文 |
ISSN
|
0922-6168;1568-5675 |
期刊性質
|
國外 |
收錄於
|
SCI; |
產學合作
|
|
通訊作者
|
Wang, San-Lang |
審稿制度
|
是 |
國別
|
荷蘭 |
公開徵稿
|
|
出版型式
|
,電子版 |