期刊論文

標題 Porcine pancreatic α-amylase inhibitors from Euonymus laxiflorus Champ
學年 105
學期 1
出版(發表)日期 2017/01/01
作品名稱 Porcine pancreatic α-amylase inhibitors from Euonymus laxiflorus Champ
作品名稱(其他語言)
著者 Nguyen, Van Bon; Nguyen, Anh Dzung; Nguyen, Quang Vinh; Wang, San-Lang
單位
出版者
著錄名稱、卷期、頁數 Research on Chemical Intermediates 43(1), p.259–269
摘要 Twenty-six samples of indigenous medicinal plants were collected in Dak Lak Province of Vietnam and evaluated for α-amylase inhibitory activity. Of these samples, trunk bark extract from Euonymus laxiflorus Champ. (ELC extract) showed the greatest α-amylase inhibitory activity with the smallest 50 % inhibitory concentration (IC50) of 6.6 ± 0.6 µg/mL against porcine pancreatic α-amylase. This extract possessed strong inhibitory activity against human saliva α-amylase and slightly lower activity against Bacillus subtilis α-amylase, with IC50 values of 4.2 ± 0.2 and 27.8 ± 1.8 µg/mL, respectively. ELC extract was found to be strongly thermostable, retaining 72–100 % relative activity even after heating at 100 °C for 5 min to 2 h. This extract was also stable at various pH values. These results suggest that ELC extract may be a good candidate for treatment of non-insulin-dependent diabetes mellitus (NIDDM) and obesity.
關鍵字 α-Amylase inhibitors;Diabetes;Obesity;Medicinal plants;Euonymus laxiflorus;Champ.;Dak Lak
語言 英文
ISSN 0922-6168;1568-5675
期刊性質 國外
收錄於 SCI;
產學合作
通訊作者 Wang, San-Lang
審稿制度
國別 荷蘭
公開徵稿
出版型式 ,電子版