期刊論文
| 學年 | 104 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2016-02-01 |
| 作品名稱 | Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo |
| 作品名稱（其他語言） | |
| 著者 | Yan, De-Yue; Ni, Lin-Kai; Chen, Ho-Lun; Chen, Li-Chou; Chen, Yau-Hung; Cheng, Chien-Chung |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Bioorganic & Medicinal Chemistry Letters 26(3), pp.774-777 |
| 摘要 | Direct coupling of a hydrophobic drug and a hydrophilic natural product via an ester bond produced an amphiphilic adduct that formed liposomes. Liposomes of resveratrol–norcantharidin adduct are capable of forming a tadpole-like nanoparticle and exhibited high toxicity in zebrafish embryos to give the better transportation and the effective concentration into cells. Using fluorescent chromophore showed the liposome in the stomach and intestinal villi rather than in the skin and muscle. This result may provide an insight into the mechanism of action of traditional Chinese medicines, which often contain a significant amount of flavonoids and polyphenol analogs. |
| 關鍵字 | Liposome;Resveratrol;Norcantharidin;Drug delivery;Tadpole structure |
| 語言 | en |
| ISSN | 0960-894X |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | Yan, De-Yue; Chen, Yau-Hung; Cheng, Chien-Chung |
| 審稿制度 | 否 |
| 國別 | GBR |
| 公開徵稿 | |
| 出版型式 | ,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/107113 ) |